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Medical Journal of Islamic Republic of Iran، جلد ۱۴، شماره ۱، صفحات ۸۳-۸۶
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عنوان انگلیسی PREVENTIVE EFFECTS OF VITAMIN B12 AND FOLIC ACID IN METHANOL-INDUCED RETINOPATHY IN AN ANIM AL MODEL
چکیده انگلیسی مقاله In order to identify the effects of vitamin B 12 and folic acid in reducing methanolinduced retinopathy, ERG waves were compared before and after methanol intoxication in rabbits. In this study 34 rabbits were divided into 4 groups. All groups received 4 g/kg of methanol intraperitoneally. In addition, the second, third and fourth groups received vitamin B 12 injection, oral folic acid and a mixture of vitamin B12 and folic acid, respectively. Baseline ERGs were recorded for all rabbits prior to intoxication and then second ERGs were taken 48-72 hours following methanol toxicity. Compared to baseline ERGs a severe reduction in the b-wave amplitude as well as reduction in the oscillatory potential were noticed. Among all groups, the first group had the most and the fourth group had the least decrease in b-wave amplitude as well as oscillatory potential. It is therefore believed that vitamin B12 has a synergistic effect with folic acid in attenuating ophthalmic toxicity of methanol in rabbits. Further studies are needed to evaluate these effects in humans.
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نویسندگان مقاله ha شهریاری | ha shahriari
from zahedan university of medical sciences, dr. shariati ave, zahedan, 98134, i.r . iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

a حسینی راد | a hosseini rad


نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-360&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Drug
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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