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Iranian Journal of Nuclear Medicine، جلد ۲۷، شماره ۱، صفحات ۵۷-۵۹
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عنوان انگلیسی 18F-FDG PET/CT findings in a possible MELAS syndrome: A case study
چکیده انگلیسی مقاله Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a rare congenital disorder of mitochondrial DNA, presenting a wide range of clinical symptoms comprising headaches, seizures, aphasia, hearing loss, visual defects, and hemiparesis. Herein we report a case of a previously asymptomatic 40-year-old male who presented with recurrent headache, seizures, Wernicke's aphasia, and impaired visual acuity. Investigations included CT, MRI, MR venography, MR spectroscopy, and PET/CT with 18F-fluorodeoxyglucose (18F-FDG-PET) of the brain. PET imaging showed diffuse increased 18F-FDG uptake in the right hemisphere and left temporal lobe; additionally, decreased 18F-FDG uptake was observed in the left frontoparietal lobe. The patient underwent treatment by levetiracetam, co-enzyme Q10, riboflavin, L-carnitine, and lacosamide, followed by improvement of his clinical signs and symptoms indicative of partial response to the therapy.
کلیدواژه‌های انگلیسی مقاله MELAS, Seizure, PET, 18F-fluorodeoxyglucose
نویسندگان مقاله Alireza Emami-Ardekani |
Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

Sara Harsini |
Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

Armaghan Fard-Esfahani |
Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

Farzaneh Baseri |
Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Eftekhari |
Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی http://irjnm.tums.ac.ir/article_33703_95cb05ea7644681ee5b0799b4c051d58.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/57/article-57-1142591.pdf
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زبان مقاله منتشر شده en
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