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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۲، صفحات ۱۶۰-۱۶۵
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عنوان انگلیسی Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma
چکیده انگلیسی مقاله Objective(s): Tanshinone IIA (T. IIA), one of the most pharmacologically active components extracted from Salviae miltiorrhiza, has anti-inflammatory and antioxidant features. The aim of the present study is to investigate the benefit of T. IIA on asthma using a murine model of asthma induced by ovalbumin (OVA). Materials and Methods: Male BALB/c mice were used in the present study. The mice were sensitized by OVA intraperitoneal injection on days 0 and 14, and received aerosolized OVA challenge for 30 min daily on days 21-23Results: T. T. IIA (10 mg/kg twice daily) intraperitoneal injection was performed on days 18-23. Results: Treatment of T. IIA reduced the levels of interleukin (IL)-4, IL-5, and IL-13 in bronchoalveolar lavage fluid (BALF) (PConclusion: T. IIA inhibits OVA-induced airway inflammation and hyperresponsiveness. T. IIA is a potential therapeutic agent for asthma.
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نویسندگان مقاله | Shi-Biao Wang
Department of Pediatric, Fujian Provincial Meternity and Children’s Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China


| Xiao-Feng Guo
Department of Pediatric, Fujian Provincial Meternity and Children’s Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China


| Bin Weng
Department of Pediatric, Fujian Provincial Meternity and Children’s Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China


| Su-Ping Tang
Department of Allergy, Fuzhou Children’s Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China


| Hui-Jie Zhang
Department of Pediatric, Fujian Provincial Meternity and Children’s Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China
نشانی اینترنتی http://ijbms.mums.ac.ir/article_12013.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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