این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Journal of Islamic Republic of Iran، جلد ۱۴، شماره ۱، صفحات ۶۱-۶۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی EPINEPHRINE SUPPRESSES SECRE TION ORVLDLASSOCIATED TRIACYLGLYCEROLAND INCREASES TRIACYLGLYCEROL AND PHOSPHOL IPID CON TEN TS IN ISOL ATED RAT HEPATOCY TES
چکیده انگلیسی مقاله The effect of epinephrine on triacylglycerol secretion was investigated in isolated rat hepatocytes. The effect appeared at concentrations of more than 1 µM and reached a plateau at 10 µM. Epinephrine concentration for half of the maximal bioeffect (EC50) was about 1 µM. Epineplrrine at a concentration of 10 µM suppressed triacylglycerol secretion by 33% and increased its cellular content by approximately 18%. The total triacylglycerol content of the system (sum of the cell and the incubation medium) was constant at all concentrations of epinephrine. Time course experiments for triacylglycerol secretion exhibited relatively similar results on the basis of lipid analysis with or without lipid extractions. On the former basis triacylglycerol secretion versus time followed a linear relationship with a slope of 1.47 ± 0.11 µmole TG/3h/ g wet liver. Time course curves of cellular lipids revealed that cellular triacylglycerol and phospholipid contents in the presence of epinephrine were higher than the control at all time points, and the difference was constant during time. Furthermore, in the presence of glucose (20 mM) and oleate (0.25 mM), intracellular triacylglycerol content increased markedly (≥45%) whereas cellular phospholipid content remained constant. It is proposed that epinephrine exerts an inhibitory effect on VLDL secretion probably through blocking in the secretory pathway.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله m رسولی | m rasouli
from the department of biochemistry, faculty of medicine, tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m شریف | m sharif
the dept. of mycology and parasitology, sari college of medical sciences, mazandaran university of medical sciences, sari, i. r.lran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

m زهرایی | m zahraie
from the department of biochemistry, faculty of medicine, tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-355&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Biological Sciences
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات