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International Journal of Pediatrics، جلد ۴، شماره ۱۱، صفحات ۳۸۷۵-۳۸۹۵
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عنوان انگلیسی Diagnostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Detection of Pediatric Acute Kidney Injury; a Systematic Review and Meta-Analysis
چکیده انگلیسی مقاله Background: Two questions about diagnostic value of urinary neutrophil gelatin associated lipocalin (uNGAL) in detection of acute kidney injury (AKI) in children have remained unanswered; first, which cut-off point of uNGAL has the highest value in detection of AKI; and second when is the best time for measuring this biomarker in a patient? Accordingly, the present study aimed to conduct a systematic review and meta-analysis to provide evidence on the diagnostic and prognostic value of uNGAL in detection of AKI in children.Materials and Methods: An extensive search in the electronic databases up to the end of August 2016 was performed. Data were summarized and then the diagnostic performance characteristics of uNGAl in AKI were evaluated.Results : Data from 37 articles were summarized. Analyses based on area under the curve, sensitivity, specificity and diagnostic odds ratio revealed that uNGAL provides the optimum prognostic and diagnostic value in detection of AKI in children when measured during 0 to 6 hours after admission or surgery with a cut-off point of 50 mg/dL. In this setting, area under the curve, sensitivity, specificity and diagnostic odds ratio of uNGAL are 0.97 (95% CI: 0.95 to 0.98), 0.92 (95% CI: 0.84 to 0.97), 0.92 (95% CI: 0.83 to 0.97) and 148.14 (95% CI: 32.13 to 683.10), respectively.Conclusion: Based on these results, measuring uNGAL during the first 6 hours after admission or surgery with a cut-off point of 50 mg/dL, provides the optimum diagnostic value in detection of AKI in children.
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نویسندگان مقاله آناهیتا ایزدی | anahita izadi
departments of pediatric infectious diseases, tehran university of medical sciences tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمود یوسفی فرد | mahmoud yousefifard
physiology research center and department of physiology, faculty of medicine, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

بابک نخجوان شهرکی | babak nakhjavan shahraki
sina trauma and surgery research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مسعود بیک پور | masoud baikpour
department of medicine, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

جلال الدین میرزای رزاز | jalaledin mirzay razaz
department of community nutrition, faculty of nutrition and food technology, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مصطفی حسینی | mostafa hosseini
department of epidemiology and biostatistics, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijp.mums.ac.ir/article_7783.html
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