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International Journal of Pediatrics، جلد ۴، شماره ۶، صفحات ۱۹۵۹-۱۹۶۵
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عنوان انگلیسی Effect of Combined versus Monotherapy with Deferoxamine and Deferiprone in Iron Overloaded Thalassemia Patients: a Randomized Clinical Trial
چکیده انگلیسی مقاله Background: Patients with transfusional iron overload have depended on iron chelation therapy and improving chelation regimens have been of the highest priority. The aim of this study was to compare effect of combined versus monotherapy with Deferoxamine (DFO) and Deferiprone (DFP) in iron overloaded beta thalassemia (BT) major patients Materials and Methods We studied 36 BT major patients (mean age 7.6±4.6; range 3–16 years) attending the Ormieh Motahari hospital for regular transfusional support. Patients were randomly allocated to receive one of the following two treatments: DFO in combination with DFP (n=12), DFO alone (n=12) and DFP alone (n=12). Serum ferritin level, liver enzymes, blood urea nitrogen, and creatinine and side effects were monitored over a 12 months period. Results: After one year, serum ferritin decreased more significantly in patients on DFO+DFP therapy compared to patients who only received DFO or DFP alone (P< 0.01). Side effects of DFP, including gastrointestinal upset (nausea, vomiting and abdominal pain) and mild agranulocytosis occurred in five (41.7%) and two (8.3%) patients, respectively but none led to discontinuation of the treatment. Conclusion: In comparison to the standard chelation monotherapy of DFO, combination treatment with additional DFP reduced serum ferritin and is effective procedure in clinical management of iron overload in patients with BT major.
کلیدواژه‌های انگلیسی مقاله Beta thalassemia, Deferoxamine, Deferiprone, Iron overload
نویسندگان مقاله ساسان حجازی | sasan hejazi
department of pediatrics, faculty of medicine, urmia university of medical sciences, urmia, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)

امید صفری | omid safari
department of pediatrics, faculty of medicine, alborz university of medical sciences, karaj, iran.


رضا ارجمند | reza arjmand
department of pediatrics, faculty of medicine, alborz university of medical sciences, karaj, iran.


مصطفی قربانی | mostafa qorbani
department of community medicine, faculty of medicine, alborz university of medical sciences, karaj, iran.


کیومرث پوررستمی | kumars pourrostami
department of pediatrics, faculty of medicine, alborz university of medical sciences, karaj, iran.


عبدالمحمد صفری | abdolmohammad safari
department of psychology, ilam branch, islamic azad university, ilam, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

آرزو همتی | arezo hemmati
department of pediatrics, faculty of medicine, alborz university of medical sciences, karaj, iran.
نشانی اینترنتی http://ijp.mums.ac.ir/article_6871.html
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