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International Journal of Pediatrics، جلد ۴، شماره ۵، صفحات ۱۸۰۳-۱۸۰۷
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عنوان انگلیسی The Association of DRD2 Gene TaqI Polymorphism with Attention Deficit Hyperactivity Disorder a Population Sample of Iranian Azeri-children
چکیده انگلیسی مقاله Background Attention deficit hyperactivity disorder (ADHD) is a multi-factorial disorder that has defined by hyperactivity, impulsivity and attention deficits. Various neurotransmitters such as dopamine can play a role in its pathophysiology. The aim of this study was to examine the association of two common single nucleotide polymorphisms in DRD2 gene, Taq I A (T/C) and Taq I B (G/A), with ADHA risk among Iranian-Azeri population. Materials and Methods A study of case–control association was performed with 89 samples with attention deficit hyperactivity disorder and 96 healthy subjects. Peripheral blood samples were used for Genomic DNA extraction by salting-out method. SNP genotyping was carried out by PCR-RFLP technique. The collected data were analyzed through javastant online statistics software, using Chi-square, with a significance level of 0.05. Results There was not a significant difference in the allele and genotype frequencies between ADHD and Taq1B polymorphism in cases and controls (P>0.05). In the Taq IA of DRD2 gene, TT homozygous dominants and CC homozygous recessives were more frequent in case group than in control group but significant difference was not observed (P>0.05). Also, T/C heterozygotes were more frequent among the control group than the case group, and difference was significant (P< 0.05). Conclusion Our data supports lack of association between Taq1A and Taq1B gene polymorphisms and ADHD.
کلیدواژه‌های انگلیسی مقاله ADHD, DRD2 gene, Biomarkers, Polymorphism
نویسندگان مقاله لیلا مهدیزاده فایند | leila mehdizadeh fanid
cognitive neuroscience, department of biology, faculty of natural sciences, university of tabriz, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

مینا adampurzare | mina adampurzare
physiology, department of biology, faculty of natural sciences, university of tabriz, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

سیدغلامرضا نورآذر | 3. seyedgholamreza noorazar
tabriz child and adolescent psychiatrist, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

محمد علی حسینپورفیضی | mohammad ali hosseinpourfeizi
radiobiology, department of biology, faculty of natural sciences, university of tabriz, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

نشانی اینترنتی http://ijp.mums.ac.ir/article_6726.html
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