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International Journal of Pediatrics، جلد ۲، شماره ۴.۲، صفحات ۵-۱۱
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عنوان انگلیسی The Ratio of Second to Fourth Digit Length (2D:4D) in Children with Autistic Disorder
چکیده انگلیسی مقاله Introduction Emerging hypotheses suggest a causal role for prenatal androgen exposure in some cases of Autism spectrum disorders (ASD). The ratios of the lengths of the bones of the 2nd to the 4th digits (2D:4D) are purported to be markers for prenatal androgen exposure and to be established early in gestation. Ratio of second and fourth digits (2D:4D) is usually used as a proxy for prenatal testosterone. Methods and Materials In this study, 2D:4D in 48 children with ASD and in 41 control child was measured. Two groups were matched with the gender and age. Both groups were selected by convenience sampling method. All statistical analyses were performed using SPSS 19.0 software, considering as significant less than .05 (p < .05). Results: Results showed that the average ratio of 2D:4D in ASD children were lower than the ratio in control children (P< 0.05(. 2D to 4D finger-length ratio of the right of children with autism was lower than the normal children (P< 0.05(; while this difference was not significant between the two groups in the left hand (P>0.05(. Conclusion: The results indicate that the 2D:4D ratio could be used together with other parameters as an indicator of the likelihood of developing autistic traits in offspring. Results achieved in this research can be valuable in further biological and psychological approaches in neurocognitive research and diagnostics of children from ASD.
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نویسندگان مقاله جواد بهارآرا | javad baharara
department of developmental biology, animal developmental of applied biology research center, mashhad branch, islamic azad university, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مریم حجتی | maryam hojjati
head of noor hedayat, center of autism spectrum disorders, mashhad, iran.


هاشم راستی | hashem rasti
phd student of developmental biology, young researchers and elite club, mashhad branch, islamic azad university, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

ملیحه سرابی جماب | malihe sarabi jamab
noor hedayat, center of autism spectrum disorders, mashhad, iran
نشانی اینترنتی http://ijp.mums.ac.ir/article_3420.html
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