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International Journal of Pediatrics، جلد ۲، شماره ۳.۱، صفحات ۱۸۹-۱۹۳
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عنوان انگلیسی Pathological evaluation of ganglion cells in biopsies from upper side of the dentate line in patients with perianal problems
چکیده انگلیسی مقاله Introduction: Constipation is one of the most common complaints of individuals, which may present with complication like hemorrhoid and fissure. Hirschsprung is a disease presenting with chronic constipation and its diagnosis may be delayed until adulthood. It is diagnosed by biopsies from anorectal transitional zone. This study aimed to evaluate the association between Hirschsprung and anorectal problems. Method: Sixty three patients with anorectal problems who underwent surgery enrolled in this study. Some consecutive biopsies were obtained from anal canal at 2, 4 and 6 cm above the dentate line. Biopsies were assessed for ganglion cells changes. Patients' data and biopsies results were analyzed with SPSS version18. Results: Out of 63 patients 29 (46 %) patients were female and 34 (54 %) were male with the mean of 32.65 ± 13.73 years. Fifty six (73 %) patients complained from constipation with the mean time of 57.65 ± 45.21 months. Aganglionic zone were reported in six patients with the mean length of 43.33 mm. There was not any relation between anal ganglion cells pathology and constipation (p=0.363), but there was a significant relation between duration of constipation and pathologic changes (p=0.001). The ratio of constipation duration to age was related to anal ganglion cell pathology (p=0.001). Hemorrhoid degree was also affected anal ganglion cells pathology (p=0.037). Conclusion: The relation between Hirschsprung's disease and anorectal problems in adults were significant. The pathologic findings were more presented in younger patients, and those with longer history of constipation and lower degree hemorrhoids. Key words: Anal ganglion cells, Hemorrhoids, Constipation
کلیدواژه‌های انگلیسی مقاله Anal ganglion cells, Hemorrhoids, Constipation
نویسندگان مقاله مرجان جودی | marjan joudi
assistant professor of surgery, surgical oncology research center, imam reza hospital, faculty of medicine, mashhad university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

علیرضا سبزواری | alireza sabzevari
assistant professor of anesthesiology. cardiac anesthesia research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

رضا نظرزاده | reza nazarzadeh
resident of fellowship of pediatric surgery, mashhad university of medical sciences. mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

رضا شریفی نوغابی | reza sharifi noghabi
4- resident of general surgery, endoscopic and minimally invasive surgery research center, ghaem hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

عامری لیلا | ameri leila
5- resident of radiology, endoscopic and minimally invasive surgery research center, ghaem hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محسن وزیری | mohsen vaziri
student of medicine, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

امین دلیلی | amin dalili
7- resident of general surgery, endoscopic and minimally invasive surgery research center, ghaem hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

عذرا ایزانلو | azra izanloo
msc in medical education, department of radiology technology, faculty of paramedical sciences, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مهدی فتحی | mehdi fathi
assistant professor of anesthesia, surgical oncology research center, imam reza hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijp.mums.ac.ir/article_2775.html
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