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International Journal of Pediatrics، جلد ۲، شماره ۲.۱، صفحات ۶۶-۶۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Antibody Response to Polysaccharide Vaccine and Switched Memory B Cells in Pediatric Patients with Inflammatory Bowel Disease
چکیده انگلیسی مقاله Background/Aims: Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract, whose etiologies are still unknown. This study was performed to evaluate the humoral immune response in terms of B cell functions in selected IBD patients. Methods: Eighteen pediatric patients with IBD, including 12 cases of ulcerative colitis (UC) and six with Crohn disease (CD), were enrolled in this study. The pneumococcal vaccine was injected in all patients, and the IgG antibody level to the polysaccharide antigen was measured before and 4 weeks after injection. The B cell switch-recombination process was evaluated. Results: Five patients with IBD (three CD and two UC) had defects in B cell switching, which was significantly higher than in controls (p=0.05). Ten patients had a specific antibody deficiency and exhibited a higher frequency of bacterial infection than the healthy group. The mean increased level of IgG after vaccination was lower in IBD patients (82.9±32.5 μg/mL vs 219.8±59.0 μg/mL; p=0.001). Among the patients who had an insufficient response, no significant difference in the number of switched memory B-cell was observed. Conclusions: A defect in B lymphocyte switching was observed in pediatric IBD patients, and especially in those patients with CD. Owing to an increased risk of bacterial infections in those patients with antibody production defects, pneumococcal vaccination could be recommended. However, not all patients can benefit from the vaccination, and several may require other prophylactic methods. (Gut Liver 2014;8:24-28)
کلیدواژه‌های انگلیسی مقاله Poster Presentation, N 47
نویسندگان مقاله gh فلاحی | gh fallahi
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a آقامحمدی | a aghamohammadi
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a خداداد | a khodadad
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m هاشمی | m hashemi
arak university of medical sciences, faculty of medicine, arak, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

p محمدی نژاد | p mohammadinejad
arak university of medical sciences, faculty of medicine, arak, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

h عسگریان عمران | h asgarian omran
arak university of medical sciences, faculty of medicine, arak, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

m نجفی | m najafi
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

f معتمد | f motamed
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

kh سلیمانی | kh soleimani
arak university of medical sciences, faculty of medicine, arak, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

h سهیلی | h soheili
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

n پروانه | n parvaneh
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

b دارابی | b darabi
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

r نصیری کالمرزی | r nasiri kalmarzi
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

sh pourhamdi | sh pourhamdi
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

h ابوالحسنی | h abolhassani
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

b mirminachi | b mirminachi
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

n رضایی | n rezaei
pediatrics center of excellence, research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijp.mums.ac.ir/article_2534.html
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