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International Journal of Pediatrics، جلد ۱، شماره ۱، صفحات ۱۹-۲۴
عنوان فارسی
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عنوان انگلیسی Characteristics and Outcome of three forms of Autoimmune Hepatitis in Iranian Children
چکیده انگلیسی مقاله Introduction To define the clinical features, biochemical and histological findings and outcome of three forms of autoimmune hepatitis. Materials and Methods In a cross sectional study between November 2001 to January 2008 in Tehran and Mashhad university of medical sciences, 61 children who diagnosed as AIH (40 girls and 21 boys) have been analyzed for their clinical, serological, and histological data. Variables analyzed included age, sex, clinical presentation, hepatic function, immunoglobulins, autoimmunity markers, histology and clinical evolution. According to the auto-antibodies profile, AIH patients were classified as type I AIH (ANA or smooth-muscle antibodies or both positive), type II (anti-LKM-1 positive) and type III (antibody negative). Results We analyzed data of 61 children with AIH. 51 patients (median age: 10 (0.7-14) years had anti-nuclear and/or smooth muscle antibody (ANA/ASMA or both), 5 (median age: 7 (2-8) years) had liver/kidney microsomal antibody (LKM-1). 5 patients had no detectable autoantibody. At presentation: 60% had jaundice or symptoms of acute hepatitis; LKM-1 positive were younger. Interface hepatitis was seen in 100% and fibrosis+/- cirrhosis were found in 70%. Frequency of AIH was 2:1 in girls. Type 1 was the most frequent diagnosis (83%) and was more frequent in older children. Relapse and treatment failure were common in type II. Conclusion AIH may have different clinical presentation in children. Althout most of cases may have high inflammatory activity or cirrhosis, good response to treatment and remission may accur.
کلیدواژه‌های انگلیسی مقاله Autoimmune hepatitis, Type 1, Type 2, child
نویسندگان مقاله مهری نجفی ثانی | mehri najafi sani
1department of pediatric gastroenterology, children medical centre hospital, tehran university of medical

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

fatemehsoltan zegheibizadeh | fatemehsoltan zegheibizadeh
2department of pediatrics, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سید علی جعفری | seyed ali jafari
2department of pediatrics, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

منور افضل آقایی | monnavar afzal aghaee
3depatment of public health, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حمید آهنچیان | hamid ahanchian
2department of pediatrics, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حمیدرضا کیانی فر | hamid reza kianifar
2department of pediatrics, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijp.mums.ac.ir/article_2029.html
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