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Medical Journal of Islamic Republic of Iran، جلد ۱۳، شماره ۳، صفحات ۲۲۵-۲۳۰
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عنوان انگلیسی IMMUNOSUPPRESSION IN HUMAN UTERINE TISSUES THROUGHOUT THE REPRODUCTIVE CYCLE
چکیده انگلیسی مقاله The purpose of this study was to investigate and compare whether the explant supernatants prepared from endometrial tissues during the proliferative phase, secretory phase and early pregnancy differ in immunosuppressive activity. Specimens of nonpregnant endometrium from hysterectomies and normal first trimester decidua following elective aspiration termination of pregnancy were obtained. Supernatants from culture of endometrium or decidual fragments were prepared after 24, 48 and 72 hours. The effect of the supernatants on mitogeninduced lymphoproliferation in vitro was assessed. The percentage of suppression was calculated and then data were evaluated using Student's t-test. The results confinned that endometrial immunosuppressive activity exists throughout the reproductive cycle and confirm that early pregnancy decidua is a source of immunoregulatory factors. Immunosuppressive activity was increased in early pregnancy decidua compared with secretory phase endometrium but the results did not reach statistical signifIcance. In contrast, the difference in immunosuppressive activity between proliferative endometrium and early pregnancy decidua was highly significant. In conclusion, the high frequency of early embryonic loss before implantation and the low success rate of in vitro fertilization (IVF), embryo transfer and pathological pregnancy in humans can be explained in part by lack of suppressor activity in the endometrium.
کلیدواژه‌های انگلیسی مقاله Immunosuppression, Pregnancy, Endometrium, Menstrual cycle.
نویسندگان مقاله مهری غفوریان بروجردنیا | mehri ghafourian boroujerdnia
from the department of immunology, medical college, ahwaz university of medical sciences


رحیم چینی پرداز | rahim chinipardaz
the department of statistics, college of sciences, shahid chamran university, ahwaz, islamic republic of iran.

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-393&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Immunology
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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