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Research in Molecular Medicine، جلد ۳، شماره ۲، صفحات ۴۵-۴۹
عنوان فارسی
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عنوان انگلیسی Association between Interleukin-8 -251T/A Polymorphism and Endometriosis in Iranian Women
چکیده انگلیسی مقاله Bachground: Endometriosis is a disease of female genital system, which is defined by the presence of ectopic endometrial tissue outside the uterine cavity. IL-8 is an autocrine growth factor in the endometrium that contributes to the pathogenesis of endometriosis. The aim of this study was to investigate the association between -251T/A polymorphism in the IL-8 gene and endometriosis risk in Iranian population. Materials and Methods: This case-control study was performed on 100 endometriosis patients and 100 healthy individuals. The IL-8 -251T/A genotypes were determined using PCR-RFLP method. The association between genotypes of the -251T/A polymorphism and the endometriosis risk was examined by use of odds ratios (OR) and 95% of confidence intervals (CIs). Results: No statistically significant associations were observed between IL-8 -251 variants and the risk of endometriosis development (&chi2: 1.02, P: 0.63). In addition, subgroup analysis according to severity of disease, were unable to identify any association between IL-8 -251T/A polymorphism and endometriosis (P>0.05), and there was no significant association between IL-8 -251T/A and the severity of endometriosis. Conclusions: This is the first study regard to association of -251T/A polymorphism with endometriosis risk. Our results indicate that the presence of the -251T/A polymorphism in IL-8 gene is not associated with the risk of endometriosis.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله فرنوش ربانی زاده | farnoosh rabbanizadeh
biology group, islamic azad university, arsanjan branch

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

لیلا کهن | leila kohan
biology group, islamic azad university, arsanjan branch

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

فاطمه السادات نجیب | fatemesadat najib
department of obstetrics and gynecology, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://rmm.mazums.ac.ir/browse.php?a_code=A-10-739-1&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده ژنتیک
نوع مقاله منتشر شده پژوهشی
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