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Medical Journal of Islamic Republic of Iran، جلد ۱۳، شماره ۳، صفحات ۱۶۱-۱۶۶
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عنوان انگلیسی RESULTS OF CYTOGENETIC ANALYSIS OF 521 AMNIOTIC FLUID CELL CULTURES (AMNIOCENTESES) PERFORMED IN IRAN
چکیده انگلیسی مقاله The indications and results of cytogenetic analysis of 521 amniotic cell cultures performed at 13-16 weeks of gestation were evaluated in this study. 507 fetuses (97.3%) were cytogenetically normal, 14 (2.7%) had unbalanced karyotypes, and 2 fetuses were found to have major abnormalities, one with anencephaly detected by measurement of alpha -fetoprotein levels in amniotic fluid and ultrasonography, and the other with a full mutation at the FMRl locus detected by molecular techniques. The unbalanced karyotypes included 2 cases each of trisomy 21, trisomy 18, triple X, 47 XXY and mosaicisms and 4 cases of various chromosomal abnormalities. 225 tests were performed for women 35 years of age or over, 6 (2.4%) abnormal karyotypes were detected, showing a 6 - fold increase over the general population. This risk was even higher (2/23,8.7%) among those parous aged >35 y who had a previous history of offspring with chromosomal aberrations. 5 of 32 (15.65%) fetuses whose parent was a carrier of a balanced chromosomal translocation or a small chromosomal marker (in one case), had unbalanced chromosomal aberrations. There were 7 cases of spontaneous abortion within 4 weeks after amniocentesis, one of which was a case of 46 XY, t (1421), + 18. Excluding this case, the rate of abortion (6/521, 1.3%) was quite below the expected rate of 2.1 % for spontaneous abortion in the 2nd trimester of pregnancy. Our data indicates that amniocentesis performed at 13-16 weeks is a safe, reliable procedure for detection of fetal chromosomal abnormalities in Iran, and we strongly recommend it for those parous at risk.
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نویسندگان مقاله a a کریمی نژاد | a a karimi nejad
from the karimi-nejad pathology and genetic center, tehran, i.r. iran.


n لشگریان | n lashgarian


mh کریمی نژاد | mh karimi nejad


نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-382&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pathology
نوع مقاله منتشر شده Original Research
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