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Journal of Medical Microbiology and Infectious Diseases، جلد ۱، شماره ۱، صفحات ۴۶-۵۱
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عنوان انگلیسی Association Between Metallo-β-lactamases and Integrons with Multi-Drug Resistance in Pseudomonas aeruginosa Isolates
چکیده انگلیسی مقاله Pseudomonas aeruginosa is among the most important pathogens in the nosocomial infections. A genetic mobile element, the integron, is one of the major agents involved in dissemination of multi-drug resistance among gram negative bacteria. During a descriptive study from October 2009 to August 2010, some 130 P. aeruginosa clinical isolates were collected from different wards of three hospitals in Tehran. The Minimal inhibitory concentration (MIC) of 4 antibiotics conventionally used in clinical settings against the isolates was determined by E-test method. Also, the existence of integron classes and metallo-β-lactamases (blaVIM-1, blaIMP-1, and blaVIM-2) were investigated by PCR assay. Out of 130 isolates, 74 (56.9%) carried class 1 integron. None of the isolates harbored integrons class 2 and 3. Also, the blaVIM-1 gene was detected in 10 (13.3%) high level ceftazidime and imipenem- resistant isolates that carried class 1 integrons. The blaIMP-1 and blaVIM-2 genes were not detected in any isolates. In the present study, the antibiotic resistance rates in class 1 integron-positive isolates of P. aeruginosa were significantly higher than those lacking this integron , e.g., 82.6% resistance versus 17.3% sensitivity to ceftazidime. Also, 13.3% of ceftazidime and imipenem resistant isolates was metallo-β-lactamase producer. This indicates that all metallo-β-lactamase genes are correlated with class 1 integrons. These results imply that the blaVIM-1 gene has been presumably dispersed into P. aeruginosa isolates with the help of class 1 integron element.
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نویسندگان مقاله سمیه اعظمی | somayeh azami
department of microbiology, faculty of sciences, alzahra university, tehran, iran

سازمان اصلی تایید شده: دانشگاه الزهرا (Alzahra university)

احیا عبدی علی | ahya abdi ali
department of microbiology, faculty of sciences, alzahra university, tehran, iran

سازمان اصلی تایید شده: دانشگاه الزهرا (Alzahra university)

عزت عسگرانی | ezzat asgarani
department of microbiology, faculty of sciences, alzahra university, tehran, iran

سازمان اصلی تایید شده: دانشگاه الزهرا (Alzahra university)

نشانی اینترنتی http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-25-13&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original article
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