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Medical Journal of Islamic Republic of Iran، جلد ۱۳، شماره ۲، صفحات ۱۳۳-۱۳۸
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چکیده فارسی مقاله
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عنوان انگلیسی MORPHINE AND APOMORPHINE INHIBIT GASTROINTESTINAL TRANSIT (GIT) THROUGH TWO DIFFERENT MECHANISMS
چکیده انگلیسی مقاله Morphine was used as a remedy for the control of diarrhea centuries before it's sedative-analgesic effect was discovered. Although several mechanisms have been proposed for the morphine-induced inhibition of gastrointestinal transit (OIT), the exact mechanism has not yet been identified. On this basis the possible involvement of the dopaminergic system in morphine-induced inhibition of transit was investigated. This study showed that morphine decreased gastrointestinal transit (OIT) of charcoal dust in mice.in a dose-dependent manner. The response was inhibited by the opiate antagonist naloxone. Pretreatment of animals with the D-2 antagonist sulpiride or the peripheral dopamine antagonist domperidone did not alter the morphine-induced inhibition of OIT. The D-l/D-2 agonist apomorphine also decreased OIT in mice. The response was inhibited by SCH 23390 or sulpiride pretreatment (p< 0.01), but not by domperidone or naloxone. It is concluded that morphine and apomorphine inhibit OIT through opiate and dopaminergic mechanisms, respectively.
کلیدواژه‌های انگلیسی مقاله Morphine, Dopamine, Gastrointestinal transit.
نویسندگان مقاله زهرا ساری | zahra sari
from the department of physiology, arak university of medical sciences, arak

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

mr زرین دست | mr zarrindast
the department of pharmacology, tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

f روشن ضمیر | f roushanzamir
the department of pharmacology, shahid beheshti university of medical sciences, tehran,l r.lran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-408&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Physiology
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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