این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Journal of Islamic Republic of Iran، جلد ۱۳، شماره ۲، صفحات ۱۲۴-۱۲۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی MODULATION OF MITOCHONDRIAL UPTAKE OF A DENOSINE BY NITROBENZYLTHIOINOSINE
چکیده انگلیسی مقاله In this study the uptake and metabolism of adenosine by mitochondria has been investigated. Incubation of CEM cells mitochondria preparation with [3H] -adenosine showed substantial uptake and metabolism of adenosine. Adenosine was both anabolized to AMP, ADP and ATP, and also catabolized to inosine. The highest concentration of metabolites in extracted mitochondria was due to AMP. The mitochondria preparation did not show any 5'-nucleotidase activity and this will exclude any possibility of the production of adenosine from AMP in the preparation. Coincubation of [3H]-adenosine with mitochondria in the presence of 2µM of a known potent nucleoside transporter inhibitor, nitrobenzylthioinosine (NBMPR), substantially reduced the mitochondria content of adenosine and its metabolites. The results of this study showed that adenosine was up taken by the mitochondria preparation. Metabolism of adenosine after incubation with CEM mitochondria provided further evidence for mitochondrial uptake and metabolism of this nucleoside.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله عبدالمجید چراغعلی | a majid cheraghali
from the department of pharmacology and toxicology, faculty of medicine, baghyatollah university of medical sciences, tehran, i.r. iran


آلان r p paterson | alan r p paterson
the department of pharmacology, university of alberta, edmonton, alberta, canada.


وندی p gati | wendy p gati
the department of pharmacology, university of alberta, edmonton, alberta, canada.
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-406&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmacology
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات