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Medical Journal of Islamic Republic of Iran، جلد ۱۳، شماره ۲، صفحات ۱۱۹-۱۲۳
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عنوان انگلیسی THE ROLE OF B-CELLS IN THE DEVELOPMENT OF IMMUNITY TO CRYPTOSPORIDIUM INFECTION
چکیده انگلیسی مقاله Studies have shown that symptomatic improvement of cryptosporidiosis in immunocompromised patients is possible following treatment with" hyperimmune" colostrum containing anti-sporozoite antibodies from cattle immunized with Cryptosporidium parvum antigens. The contribution to immunity of antibodies developed during Cryptosporidium infection is unclear, however. Previously, we showed that SCID ( severe combined immunodeficiency) mice acquired immunity to C. muds infection if injected with immunocompetent splenocytes. To investigate the role of the splenic donor B-cells in this immunity, groups of CB-17 SCID mice received BALB/c splenocytes, or splenocytes depleted of B-cells by immunomagnetic separation before infection. Both groups recovered from infection at similar times and displayed little difference in patterns of oocyst excretion. Subsequently, B-cells and serum anti-parasite antibodies were found only in mice reconstituted with unfractionated spleen cells. These results suggested that Bcells may not normally be required in immunity against Cryptosporidium.
کلیدواژه‌های انگلیسی مقاله Cryptosporidium, B-cell
نویسندگان مقاله mh دوامی | mh davami
from the dept. of immunology, arak university of medical sciences, p.o. box 646, arak, islamic republic of iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

v مک دوناذ | v mcdonald
the molecular immunology unit, department of clinical sciences, london school of hygiene and tropical medicine lshtm , keppel street, london wcie 7ht, england.
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-405&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Immunology
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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