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Medical Journal of Islamic Republic of Iran، جلد ۱۳، شماره ۲، صفحات ۱۱۵-۱۱۸
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عنوان انگلیسی RELAPSE RATE IN DAILY SINGLE-DOSE PREDNISOLONE THERAPY FOR CHILDREN WITH PRIMARY NEPHROTIC SYNDROME
چکیده انگلیسی مقاله Most current references recommend divided doses of prednisolone for the initial treatment of idiopathic minimal change nephrotic syndrome in children, with relapse occuring in the majority of them, but there is little experience concerning single-dose prednisolone therapy, especially considering the relapse rate. In this prospective study on 36 consecutive children with primary nephrotic syndrome, prednisolone (2 mg/kg/day) was used as a single daily dose in 17 patients (SD group), or divided into 3 doses in 19 cases (DD group) who were randomly selected, and relapse rates were compared. The mean age of the patients was 6 years (range 15 months-I3 years)• and there was no statistically significant difference between the two groups considering age, sex, clinical presentation, laboratory findings at the time of admission and prednisolone side effects. After 4 weeks of full dose prednisolone therapy, the drug was changed to 2 mg! kg as a single dose every other day in both groups, irrespective of the response. During the third month of therapy, the drug was reduced to 1 mg/kg every other day and it was discontinued after 4 weeks. Relapse rate was compared in steroid responsive patients in both groups (14 in the SD and 11 in the DD group) who were matched for age, sex and paraclinical findings. During the first year of follow-up, in those who were initially steroid responsive, 2 patients in the SD and 6 in the DD group had no relapse. The number of total relapses/year in the SD and DD group were 19 for 12 patients and 8 for 5 patients respectively (p
کلیدواژه‌های انگلیسی مقاله Prednisolone, single daily dose, nephrotic syndrome, relapse
نویسندگان مقاله mh فلاح زاده | mh fallahzadeh
from the department of pediatric nephrology, shiraz university of medical sciences, shiraz, i.r.lran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

gh هاشمی | gh hashemi


m شریعتی | m shariati


نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-404&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pediatric Nephrology
نوع مقاله منتشر شده Original Research
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