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Medical Journal of Islamic Republic of Iran، جلد ۳۰، شماره ۱، صفحات ۱۴۱-۱۴۵
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عنوان انگلیسی The effect of alendronate treatment on cortical thickness of the proximal femur in postmenopausal women
چکیده انگلیسی مقاله Background: Bisphosphonates (BPs) are used extensively for managing the osteoporosis. There are some controversies on atypical fractures of femur that associated with increase in cortical thickness (CT) and BPs' use. In this study, the effects of alendronate consumption were studied on femoral CT as a predictor for atypical fracture. Methods: Forty nine post-menopausal women aged 50-70 years with osteopenia-osteoporosis who were treated with alendronate 70 mg/week for at least one year were compared to 49 controls for CT in subtrochanteric region of femur by hip dual-energy X-ray absorptiometry (DXA) scans and hip X-ray. CT and its ratio were measured at 3.5 and 4.0 cm below the tip of the greater trochanter (GT) and 0.5 cm below lesser trochanter (LT) in DXA and at 9.5 and 10.5 cm of GT and 1 cm of LT in X-ray. Results: In this study, 98 women participated whose mean age and age at menopause were 60 (17±5.6) and 49 (40±2.7) years, respectively. Duration of BP consumption in alendronate group was 1.76±1.38 (1-10) years. No difference was seen in the mean of CT and its ratio between the alendronate and control groups in BMD scan or X-ray. The best correlation between two imaging modalities was in cortical ratio in 3.5 cm of GT in BMD scan and 9.5 cm of GT in X-ray. Conclusion: Alendronate treatment did not appear to increase femoral CT throughout the detection limits of BMD scan or X-ray. 
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نویسندگان مقاله مریم مبینی | maryam mobini
diabetes research center, mazandaran university of medical sciences, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

لیلا دهقان | leyla dehghan
division of internal medicine, imam khomeini hospital, mazandaran university of medical sciences, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

غلامعلی یوسفی | gholamali yosefi
valiasr hospital, mazandaran university of medical sciences, ghaemshahr, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

رضاعلی محمدپور | reza ali mohammadpour
diabetes research center, mazandaran university of medical sciences, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

روح اله عبدی | rohollah abdi
mazandaran university of medical sciences, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-1018&slc_lang=en&sid=en
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