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Medical Journal of Islamic Republic of Iran، جلد ۱۲، شماره ۳، صفحات ۲۷۹-۲۸۳
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عنوان انگلیسی HYPERVITAMINOSIS A-INDUCED CENTRAL NERVOUS SYSTEM DEFECTS
چکیده انگلیسی مقاله In this investigation the effects of excess vitamin A administration during the early embryonic period were studied. Intramuscular injection of a single dose of 15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (CNS) including exencephaly, hydrocephalus, microcephalia, spina bifid a and myelocystocele and also a few other defects such as limb malformations. The incidence and severity of these malformations was positively correlated with the dosage and time of exposure. Among experimental groups, the most effective dose of vitamin A which produced a high incidence of CNS defects was 25000 IU/kg injected on day 8 of gestation (35%) compared to the control group (0%). Histological studies on 18 day old experimental fetuses revealed spina bifid a with and/or without spinal cord defect. These studies showed excessive embryonic cell death localized in the neural tube region following vitamin A exposure. In conclusion, excess vitamin A exposure in the early days and critical periods of development may interfere with certain developmental phenomena, resulting in various detectable CNS defects among newborn infants.
کلیدواژه‌های انگلیسی مقاله Vitamin A, neural tube defect, neurolation.
نویسندگان مقاله مهدی جلالی | mehdi jalali
from the department of anatomy, school of medicine, mashhad university of medical sciences, mashhad, islamic republic of iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

علیرضا فاضل | alireza fazel


نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-458&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Anatomical Sciences
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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