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Medical Journal of Islamic Republic of Iran، جلد ۱۲، شماره ۳، صفحات ۲۰۵-۲۰۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی COMPARISON OF THE BRONCHODIL ATORY EFFECTS OF INHALED SALBUTAMOLAND COMBIVEN T IN ASTHMATIC PATIENTS
چکیده انگلیسی مقاله A randomized, double-blind, crossover trial was designed to compare the acute effects of Combivent and salbutamol on spirometric parameters in patients with moderate to severe asthma. Nineteen patients with a mean baseline forced expiratory volume in 1 sec. (FEV]) less than 65% predicted, were randomized on two separate days to receive two puffs of salbutamol (200 µg) or two puffs of Combivent (200 µg salbutamol plus 40 µg of ipratropium bromide) by metered dose inhalers. On study days using spirometry, FEV!, forced vital capacity (FVC), maximal mid-expiratory flow rate (MMEF) and peak: expiratory flow rates (PEFR) were measured at baseline and at 15, 60 and 180 minutes after drug administration. Blood pressure and pulse rate were also determined before and 3 hours post drug inhalation. The results of this study show that Combivent produces significantly greater improvement compared to salbutamol in all four spirometric parameters at 15, 60, and 180 minutes after drug treatment. The greatest differences between the bronchodilating effects of the two re!imens were observed at 180 minutes after drug inhalation. There were no clinically significant changes in heart rate or blood pressure. It may therefore be concluded that in patients with moderate to severe asthma, Combivent provides better bronchodilation than salbutamo1 alone at clinically relevant doses without increasing side-effects
کلیدواژه‌های انگلیسی مقاله Asthma, bronchodilator, Combivent, ipratropium, salbutamol.
نویسندگان مقاله g درخشان دیلمی | g derakhshan deilami
from the division of pulmonology, imam khomeini hospital, tehran university of medical sciences,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a غلامحسینی | a gholamhosseini
the department of pharmacology, shaheed beheshti university of medical sciences, tehran, islamic republic of iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

mh پورغلامی | mh pourgholami
the department of pharmacology, shaheed beheshti university of medical sciences, tehran, islamic republic of iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-446&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmacology
نوع مقاله منتشر شده Original Research
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