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Medical Journal of Islamic Republic of Iran، جلد ۳۰، شماره ۱، صفحات ۸۵-۹۲
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عنوان انگلیسی Prevalence of hepatic steatosis and associated factors in Iranian patients with chronic hepatitis C
چکیده انگلیسی مقاله Background: Hepatic steatosis is commonly observed in patients with chronic hepatitis C (CHC). Many studies indicate a relationship between steatosis and fibrosis progression. The aim of this study was to analyze the prevalence of hepatic steatosis and related factors in Iranian CHC patients. Methods: One hundred and fifteen consecutive patients with CHC were enrolled which were treatment-naïve. The patients were divided into groups with and without steatosis according to the result of liver biopsy (58.3% and 41.7%, respectively). Demographic, histological, biochemical and virological factors were examined and compared in all patients. Results: In terms of host factors, body mass index (BMI), triglyceride, fasting blood glucose (FBG), necroinflammatory activity and severity in fibrosis of CHC patients with steatosis was significantly higher than the patients without steatosis. Of viral factors, HCV viral load was not significantly altered in patients with steatosis. Moreover, HCV genotypes did not meet such association. Using multivariate regression analysis, parameters of BMI values, FBG level and stage of fibrosis were independently associated with steatosis. Conclusion: Our data indicate that CHC patients are more susceptible to development of hepatic steatosis. Based on our results, grade of steatosis appears to be associated with hepatic fibrosis progression rate in CHC patients.
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نویسندگان مقاله وحدت پورطهماسبی | vahdat poortahmasebi
hepatitis b molecular laboratory, department of virology, school of public health, tehran university of medical sciences, teh-ran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Hepatitis B Molecular Laboratory

محمد سجاد امامی آل آقا | mohammad sajad emami aleagha
department of clinical biochemistry, faculty of medical sciences, tarbiat modares university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

مهدی امیری | mehdi amiri
department of cell biology and anatomy, schulich school of medicine and dentistry, western university, london, on, canada.


مصطفی قربانی | mostafa qorbani
department of community medicine, alborz university of medical sciences, karaj, iran amp; non-communicable disease research center, endocrinology and metabolism population sciences institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد فرهمند | mohammad farahmand
virology department, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حمید آسایش | hamid asayesh
department of medical emergencies, qom university of medical sciences, qom, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قم (Qom university of medical sciences)

سید موید علویان | seyed moayed alavian
middle east liver diseases meld center, tehran, iran.

سازمان های دیگر: Middle East Liver Diseases (MELD) Center

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-956&slc_lang=en&sid=en
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