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The Archives of Bone and Joint Surgery، جلد ۷، شماره ۲، صفحات ۷۹-۹۰
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عنوان انگلیسی The Role of Gene Therapy in Cartilage Repair
چکیده انگلیسی مقاله The key principle of gene delivery to articulations by direct intra-articular injection is to release complementary DNA(cDNA)-encoding medical products that will lead to maintained, endogenous production of the gene products withinthe articulation. In fact, this has been accomplished for both in vivo and ex vivo gene delivery, using several vectors,genes, and cells in some animal models. Some clinical trials for rheumatoid arthritis and osteoarthritis (OA) usingretrovirus vectors for ex vivo gene delivery and adeno-associated virus (AAV) for in vivo delivery have been reported.AAV is of special attention because, contrary to other viral vectors, it can enter deep within joint cartilage and transducechondrocytes in situ. This quality is of special significance in OA, in which modifications in chondrocyte metabolismare believed to be crucial to the pathophysiology of the disease. The clinical effectiveness of TissueGene-C (TG-C), acell and gene therapy for OA consisting of nontransformed and transduced chondrocytes (3:1) retrovirally transducedto overexpress TGF-β1 has been reported in patients with knee OA. The most common complications of TG-C wereperipheral edema (9%), arthralgia (8%), articular swelling (6%), and injection site pain (5%). TG-C was associatedwith relevant ameliorations in function and pain. Gene therapy appears to be a viable method for the management ofarticular cartilage defects and OA.Level of evidence: III
کلیدواژه‌های انگلیسی مقاله cartilage, Gene Therapy, Injury, repair
نویسندگان مقاله | E. Carlos RODRIGUEZ-MERCHAN
Department of Orthopaedic Surgery and La Paz Research Institute (“Instituto de Investigación La Paz – IdiPaz”), “La Paz” University Hospital, Madrid, Spain


| Leonard A. Valentino
Rush University, Chicago, Illinois, USA
نشانی اینترنتی http://abjs.mums.ac.ir/article_11647.html
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده CURRENT CONCEPTS REVIEW
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