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Medical Journal of Islamic Republic of Iran، جلد ۳۳، شماره ۱، صفحات ۶-۱۰
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عنوان انگلیسی Oral herbal supplement containing magnesium sulfate improve metabolic control and insulin resistance in non-diabetic overweight patients: A randomized double blind clinical trial
چکیده انگلیسی مقاله Background: Magnesium deficiency plays a key role in obesity and decreases insulin sensitivity. In our previous study, significant evidence was provided for the contribution of oral Mg supplement that could improve insulin sensitivity and body weight in animal trials. The purpose of the present study was to investigate the effects of an herbal supplement containing 300 mg magnesium sulfate on lipid profile, as well as insulin resistance and secretion in overweight patients.    Methods: Seventy overweight non-diabetic volunteers with Body Mass Index (BMI) >28 kg/m2 were included in a randomized double blind placebo-controlled clinical trial (ethic number HUMS REC.1394.57) and registered in Iranian Registry of Clinical Trials (IRCT2012110124756N2 with registration number 24756). They received either placebo or an herbal supplement capsule containing 300 mg magnesium sulfate (MgSO4) for 6 months on a daily basis. Metabolic control, lipid profile and magnesium status were determined at baseline and every three months. Student t-test, repeated measure ANOVA and ANCOVA were used to compare the groups.    Results: There was no significant difference between groups before intervention, but daily Mg supplement for 6 months significantly improved fasting insulin level (6.71±0.11 to 6.27±0.3 three months after Mg therapy, p< 0.01 vs. 6.41±0.11 in control group (5.83±0.063)  six months after Mg therapy, p< 0.0001),  HOMA-IR (1.52±0.03 )in control group to 1.36±0.03 after three months Mg therapy, p< 0.05 vs 1.37±0.05 in control group to 1.22±0.02 six months after Mg therapy, p< 0.05), high density lipoprotein cholesterol (HDL) (43.57±0.82 in control group to 43.91±1.92 three months after Mg therapy, p< 0.001vs 43.57±0.82 in control group to 46±0.88 six months after Mg therapy, < 0.01), triglyceride (TG) (163.17±6.1 in control group to 141.2±5.84 six months after g therapy, p< 0.05) and low density lipoprotein cholesterol (LDL) (112.62±3.41 in control group to 104.42±2.35 six months after Mg therapy, p< 0.05).    Conclusion:  Oral herbal supplement containing MgSO4 (300 mg/day) could improve plasma insulin level, lipid profile, and insulin resistance in non-diabetic overweight volunteers.  
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نویسندگان مقاله | Mehrdad Solati
Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Leila Kazemi
Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Naghi Shahabi Majd
Department of Basic Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mansoor Keshavarz
Department of Physiology, Faculty of Medicine, Tehran University of Medical Sci-ences, Tehran, Iran


| Nima Pouladian
English Language Department, school of medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Nepton Soltani
Department of Physiology, School of Medicine, Isfahan University of Medical Sci-ences, Isfahan, Iran, & Cardiovascular Research Center for Hormozgan University of Medical Sciences, Bandar Abbas, Iran
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-617-2&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/18/article-18-1288617.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Endocrinology
نوع مقاله منتشر شده Original Research
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