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Medical Journal of Islamic Republic of Iran، جلد ۳۳، شماره ۱، صفحات ۱-۵
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عنوان انگلیسی Cognitive profile and determinants of poor cognition in people without dementia in Parkinson’s disease
چکیده انگلیسی مقاله Background: The Montreal Cognitive Assessment (MoCA) has been recommended as a cognitive screening tool for clinical practice and research in Parkinson's disease (PD), yet no normative data have been published for MoCA in PD without dementia.     Methods: We undertook a pooled secondary analysis of data from two studies (one cross-sectional design and one clinical trial) conducted in the East of England region. All participants were aged 18 years or over, met UK Brain Bank criteria for PD and did not have clinical dementia. Cognitive status was assessed using MoCA at baseline in both studies. The influences of age, gender, disease duration, medication load (LEDD) and mood (HADS) on cognition were examined using regression analysis.    Results: Data from 101 people with PD without dementia were available (mean age 71 years, 66% men). Median (IQR) MoCA was 25(22, 27). Age was found as the only predictor of MoCA in this sample. People aged over 71 had poorer MoCA (Beta=0.6 (95%CI 0.44, 0.82)) and an increased odds of MoCA < 26 (Beta=0.29 (95%CI 0.12, 0.70)) as well as poorer scores on several MoCA sub-domains.    Conclusion: We present the normative data for MoCA in people with PD without clinical dementia. Age appeared to be the only associated factor for lower level of cognition, suggestive of Mild cognitive impairment in PD (PD-MCI) in PD without clinical diagnosis of dementia.  
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نویسندگان مقاله | Max Barnish
Institute for Health Research, College of Medicine and Health, University of Exeter, Exeter, UK


| David J Daley
Norwich Medical School, University of East Anglia, Norwich, UK


| Katherine HO Deane
School of Health Sciences, University of East Anglia, Norwich, UK


| Allan B Clark
Norwich Medical School, University of East Anglia, Norwich, UK


| Richard J Gray
Department of Nursing, La Trobe University, Melbourne, Australia


| Simon MC Horton
School of Health Sciences, University of East Anglia, Norwich, UK


| Zoe R Butterfint
School of Health Sciences, University of East Anglia, Norwich, UK


| Phyo K Myint
Aging Clinical and Experimental Research (ACER) Team, School of Medicine, Medical Sciences, and Nutrition, University of Aberdeen, Aberdeen, UK
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-1118&slc_lang=other&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/18/article-18-1288618.pdf
کد مقاله (doi)
زبان مقاله منتشر شده other
موضوعات مقاله منتشر شده Epidemiology
نوع مقاله منتشر شده Original Research
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