این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Journal of Islamic Republic of Iran، جلد ۱۱، شماره ۴، صفحات ۳۲۹-۳۳۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی BRONCHODILATORY AND AN TICHOLINERGIC EFFECTS OF Carum copticum ON ISOLATED GUINEA PIG TRACHEAL CHAINS
چکیده انگلیسی مقاله Carum copticum is a grassy and annual plant which is believed to have several therapeutic effects, including anti-asthmatic properties. We have therefore studied the bronchodilatory and anticholinergic effects of 4 rnL aqueous extract (AE), 0.0 5 mL ethanol extract (EE), and 0.0 0 5 mL essential oil (EO) of Carum copticum and 1 rnL of a 5 mM solution of its main ingredient, thymol (T), in comparison with 4 mL of saline (S) on isolated tracheal chains of guinea-pigs (w=500-800 g) in a 50 mL organ bath. The bronchodilatory effects of different solutions were examined by their relaxant effect on isometrically (1 g) precontracted tracheal chains by 10 µM methacholine (M). The anticholinergic effects of different solutions were tested by comparing the cumulative log concentration -response curves of tracheal chains to cumulative concentrations of M in the presence of AE, EE, EO, and T with that of S. The bronchodilatory effects of AE, EE, and EO were significantly higher than S in all cases (p< 0.00 1), but T did not show any significant bronchodilatory effect. There were also significant right-ward shifts in cumulative log concentrationresponse curves obtained in the presence of AE, EE, and EO in comparison with the curve obtained in the presence of S. Thymol also caused a smaller right-ward shift in the M cumulative log concentration-response curve . However, the slopes of methacholine response curves obtained in the presence of AE, EE, EO (p< 0 .00 l ), and T (p< 0.05) were significantly lower than that of S, indicating the functional antagonistic effects of these solutions. These data showed the presence of bronchodilatory effects of AE, EE, and EO of Carum copticum which was not due to the presence of T or the existence of a competitive antagonist at the muscarinic receptors in this plant.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله mh بسکابادی | mh boskabady
from the dept. of physiology, ghaem medical center, mashhad university of medical sciences, mashhad, i. r.lran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

h rakhshandah | h rakhshandah


v معتمد شریعتی | v moetamed shariati


نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-337&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Physiology
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات