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Medical Journal of Islamic Republic of Iran، جلد ۱۱، شماره ۴، صفحات ۳۰۳-۳۰۶
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عنوان انگلیسی EFFEC T OF HUMAN GROWTH HORMONE TREATMEN T IN CHILDREN WI TH GROWTH HORMONE DEFICIENCY, TURNER'S SYNDROME AND ACHONDROPLASIA: A COMPARISON OF DOSE FREQUENCY AND ROU TE OF ADMINIS1RATION
چکیده انگلیسی مقاله Recombinant human growth hormone (hGH) was given for 6 months or longer to 68 patients with GH deficiency, 6 with Turner's syndrome and 5 with achondroplasia, during 1986-1994 in a prospective study. The total weekly administered dose of GH was 0.6 u/kg. By random sampling, 29 of 68 GH deficient patients (42.6%) received twice weekly (2 iw) intramuscular (im) injections, 17 (25%) received twice weekly subcutaneous (sc) injections and 22 received hGH 6 times per week (6 iw) sc during the first 6 months of therapy. In the GH deficient group the mean pretreatment height velocity was 4 ± 1.2 cm! yr (mean ±SD). The mean velocity during the first 6 months of treatment was 8.7 ± 2.3 cm/yr (p< 0.0005), regardless of the frequency and type of GH administration. During the second 6 months and second year of treatment, the mean growth rates were 7.7 ± 2.2 and 6.7 ± 2.2 cm, respectively. The mean increase in height during the first 6 months of therapy for the 2 iw im group (7.7 ± 1.6 cm) compared with the 2 iw sc group (7.6 ± 2.1) did not exhibit any significant difference (0.8
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نویسندگان مقاله z کرمی زاده | z karamizadeh
from the department of pediatrics, shiraz university of medical sciences, shiraz, islamic republic of iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

gh امیرحکیمی | gh amirhakimi


نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-331&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pediatric
نوع مقاله منتشر شده Original Research
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