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Medical Journal of Islamic Republic of Iran، جلد ۱۱، شماره ۳، صفحات ۲۲۳-۲۲۸
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عنوان انگلیسی EFFECT OF FIVE ALPHA DIHYDROTESTOSTERONE (5α-DHT) ON CYTOKINE PRODUCTION BY PERITONEAL MACROPHAGES OF NZB/BALBc MICE
چکیده انگلیسی مقاله One of the mechanisms involved in the regulation of the immune system by steroid hormones could be the monocytic-macrophage system. In this study the effect of the male hormone 5a-DHT on cytokine release by peritoneal macrophages (mΦ) of male and female NZB/BALBc mice was investigated. Macrophages from male mice activated with LPS produced a greater amount of IL-1β (21.8%) (p< 0.05) and IL-6 (19.3% ) (p< 0.0 1) than age-matched females. However, the total amount of TNF-α released by LPS-activated macrophages was greater (24.8%) (p< 0.05) in female than male mice. 5α -DHT enhanced IL-1β and reduced IL-6 release by activated macrophages in a dose-dependent fashion. The effect of 5aD HT on TNF-α release was not exactly dose-dependent Therefore, it is likely that the modulation of the immune system by steroid hormone may partly be due to the effect of 5α -DHT on the secretion of cytokines by the monocytic-macrophage system.
کلیدواژه‌های انگلیسی مقاله Macrophage, Sex hormone, 5α-DHT, Cytokine.
نویسندگان مقاله کاظم احمدی رنانی | kazem ahmadi renani
from the department of immunology, faculty of medicine baghiatollah university of medical sciences, tehran, islamic republic of iran


آلان b mccruden | alan b mccruden
the department of immunology, university of strathclyde, glasgow, g4 onr, u.k.
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-355&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Physiology
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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