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Acta Medica Iranica، جلد ۵۶، شماره ۵، صفحات ۲۸۷-۲۹۴
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عنوان انگلیسی Role of Nitric Oxide and Metallothionein in Cytotoxic Activity of Cadmium in Caco-2 Cells
چکیده انگلیسی مقاله Cadmium (Cd) induces carcinogenicity and cytotoxicity through a variety of mechanisms. Metallothioneins (MTs) play critical roles in metal detoxification and radical scavenging. Here we evaluated the possible involvement of NO and MT in Cd-induced toxicity and resistance development. By utilizing Cd-resistant Caco-2 cells as a model of chronic exposure to Cadmium, we observed that Cd decreased Caco-2 cell proliferation, whereas Cd-resistant cells showed a lower sensitivity to Cd cytotoxicity. L-NAME as an iNOS inhibitor and cPTIO as an NO scavenger induced a significant reduction in Cd-mediated toxicity of parent Caco-2 in spite of resistant cells. In resistant cells, iNOS mRNA expression was declined; however, MT protein synthesis was increased following acute and chronic Cd exposure. It seems that NO synthesis involves in Cd-induced cytotoxicity, while elevated MT expression is associated with Cd detoxification and resistance.
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نویسندگان مقاله | Farnaz Malekmarzban
Department of Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.


| Mohammad Seyedabad
Department of Pharmacology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.


| Mohammad Hossein Ghahreman
Department of Toxicology and Pharmacology, School of Pharmacy and Poisoning Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Shima Aliebrahimi
Department of Cellular and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.


| Peiman Habibollahi
Department of Toxicology and Pharmacology, School of Pharmacy and Poisoning Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Shohreh Tavajohi
Department of Toxicology and Pharmacology, School of Pharmacy and Poisoning Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Seyed Nasser Ostad
Department of Toxicology and Pharmacology, School of Pharmacy and Poisoning Research Center, Tehran University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/6118
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-1353281.pdf
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