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The Journal of Tehran University Heart Center، جلد ۱۲، شماره ۲، صفحات ۶۵-۷۱
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عنوان انگلیسی Effect of endothelial and mesenchymal stem cells on improving myocardial function
چکیده انگلیسی مقاله Background: Myocardial infarction is the main cause of death worldwide. Angiogenesis, a promising new therapy for the treatment of diffuse coronary artery disease, shows a poor response to conventional revascularization techniques. This study focused on improving myocardial function using endothelial cells (ECs) and mesenchymal stem cells (MSCs) in a sheep animal model. Methods: Acute myocardial infarction was induced in 18 sheep (12 treated cases and 6 controls). Autologous MSCs and ECs were injected in the infarcted area and the border zone. Two months after transplantation, echocardiography, electron microscopy, and immunohistochemistry were performed. Results: Echocardiography in both MSC and EC groups revealed a significant improvement in the ejection fraction compared with the control group (p value < 0.05). Vascular density, estimated by antibodies against the von Willebrand factor and smooth muscle actin, increased in both study groups. The pattern of vascularity in the MSC and EC groups was diffused. The electron microscopic evaluation of the infracted areas revealed cardiomyocytes in variable stages of development in the border zone in both EC and MSC groups. Conclusion: Both ECs and MSCs were able to promote angiogenesis and improve cardiac function. Presumably, MSCs differentiate into ECs and cause angiogenesis as it occurs for ECs.
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نویسندگان مقاله | Shahram Rabbani
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran


| Masoud Soleimani
Tarbiat Modares University, Tehran, Iran.


| Mohammad Sahebjam
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.


| Mohammad Imani
Iran Polymer and Petrochemical Institute, Tehran, Iran.


| Seyed Mahdi Nassiri
Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.


| Amir Atashi
Stem Cell and Tissue Engineering Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.


| Morteza Daliri Joupari
National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.


| Ali Ghiaseddin
Tarbiat Modares University, Tehran, Iran.


| Payman Latifpour
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.


| Seyed Hossein Ahmadi Tafti
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://jthc.tums.ac.ir/index.php/jthc/article/view/624
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/65/article-65-1353628.pdf
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