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The Journal of Tehran University Heart Center، جلد ۸، شماره ۱، صفحات ۳۵-۴۱
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عنوان انگلیسی Comparison of Right and Left Side Heart Functions in Patients with Thalassemia Major, Patients with Thalassemia Intermedia, and Control Group
چکیده انگلیسی مقاله Background: Heart disease is the main cause of mortality and morbidity in patients with beta thalassemia, rendering its early diagnosis vital. We studied and compared echocardiographic findings in patients with beta thalassemia major, patients with beta thalassemia intermedia, and a control group. Methods: Eighty asymptomatic patients with thalassemia major and 22 asymptomatic cases with thalassemia intermedia (8-25 years old) were selected from those referred to Ali Asghar Hospital (Zahedan-Iran) between June 2008 and June 2009. Additionally, 80 healthy individuals within the same age and sex groups were used as controls. All the individuals underwent echocardiography, the data of which were analyzed with the Student t-test. Results: The mean value of the pre-ejection period/ejection time ratio of the left ventricle during systole, the diameter of the posterior wall of the left ventricle during diastole, the left and right isovolumic relaxation times, and the right myocardial performance index in the patients with beta thalassemia major and intermedia increased significantly compared to those of the controls, but the other parameters were similar between the two patient groups. The mean values of the left and right pre- ejection periods, left ventricular end systolic dimension, and left isovolumic contraction time in the patients with thalassemia intermedia increased significantly compared to those of the controls. In the left side, myocardial performance index, left ventricular mass index, isovolumic contraction time, and deceleration time exhibited significant changes between the patients with thalassemia major and those with thalassemia intermedia, whereas all the echocardiographic parameters of the right side were similar between these two groups. Conclusion: The results showed that the systolic and diastolic functions of the right and left sides of the heart would be impaired in patients with thalassemia major and thalassemia intermedia. Consequently, serial echocardiography is suggested in asymptomatic patients with beta thalassemia for an early diagnosis of heart dysfunction and proper treatment.
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نویسندگان مقاله | Noormohammad Noori
Children and Adolescent Health Research Center, Aliebne Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.


| Mehdi Mohamadi
Children and Adolescent Health Research Center, Aliebne Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.


| Kambiz Keshavarz
Imam Sajad Hospital, Yasuj University of Medical Sciences, Yasuj, Iran.


| SeyedMostafa Alavi
Rajaei Cardiovascular, Medical and Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Maziar Mahjoubifard
Children and Adolescent Health Research Center, Aliebne Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.


| Yalda Mirmesdagh
Rajaei Cardiovascular, Medical and Research Center, Tehran University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://jthc.tums.ac.ir/index.php/jthc/article/view/279
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