این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
The Journal of Tehran University Heart Center، جلد ۷، شماره ۳، صفحات ۱۱۷-۱۲۰
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عنوان انگلیسی Pregnancy Outcome after Mechanical Mitral Valve Replacement: A Prospective Study
چکیده انگلیسی مقاله Background: Pregnant patients with mechanical heart valves require anticoagulation. The risk of bleeding and embryopathy associated with oral anticoagulants must be weighed against the risk of valve thrombosis. Methods: In this prospective study, undertaken between 1999 and 2009, 53 pregnancies (47 women with mechanical mitral valves; 29.8 ± 4.8 years old) were studied. Patients were divided into two groups: group I (n = 43) received Warfarin throughout the pregnancy, while group II (n = 10) received Heparin in the first trimester and then Warfarin until the 36th week. Results: Thirty-two (60.4%) pregnancies resulted in live births, whereas 18 (34%) abortions, 2 (3.8%) stillbirths, and one (1.9%) maternal death occurred. In group I, there were 26 (60.5%) live births, one (2.3%) stillbirth, and 15 (34.9%) abortions. In group II, there were 6 (60%) live births, one (10%) stillbirth, and 3 (30%) abortions. There were no significant differences between the two groups in terms of fetal outcome. Thirty-nine (90.7%) of the pregnancies in group I and 50% of those in group II (p value = 0.001) were without complications. There were no congenital malformations in the two groups. Conclusion: Fetal outcome was almost the same between the Warfarin and Heparin regimens. In maternal outcome, the Warfarin regimen is safer than Heparin.    
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نویسندگان مقاله | Niloufar Samiei
Heart Valve Disease Research Center, Rajaei Cardiovascular Medical and Research Center, Tehran
 University of Medical Sciences, Tehran, Iran.


| Fahimeh Kashfi
Heart Valve Disease Research Center, Rajaei Cardiovascular Medical and Research Center, TehranUniversity of Medical Sciences, Tehran, Iran. AND Reproductive Epidemiology Research Center, Royan Institute, ACECR, Tehran, Iran.


| Amirjamshid Khamoushi
Heart Valve Disease Research Center, Rajaei Cardiovascular Medical and Research Center, Tehran
 University of Medical Sciences, Tehran, Iran.


| Saeid Hosseini
Heart Valve Disease Research Center, Rajaei Cardiovascular Medical and Research Center, Tehran
 University of Medical Sciences, Tehran, Iran.


| Alireza Alizadeh-Ghavidel
Heart Valve Disease Research Center, Rajaei Cardiovascular Medical and Research Center, Tehran
 University of Medical Sciences, Tehran, Iran.


| Robabeh Taheripanah
Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Yalda Mirmesdagh
Heart Valve Disease Research Center, Rajaei Cardiovascular Medical and Research Center, Tehran
 University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://jthc.tums.ac.ir/index.php/jthc/article/view/258
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/65/article-65-1353683.pdf
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