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Iranian Journal of Parasitology، جلد ۱۰، شماره ۳، صفحات ۳۸۹-۴۰۱
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عنوان انگلیسی Interleukin-18 Antagonism Improved Histopathological Condi¬tions of Malaria Infection in Mice
چکیده انگلیسی مقاله Background: Interleukin 18 (IL-18) exerts pleiotropic roles in many inflammatory-related diseases including parasitic infection. Previous studies have demonstrated the promising therapeutic potential of modulating IL-18 bioactivity in various pathologi­cal conditions. However, its involvement during malaria infection has yet to be established. In this study, we demonstrated the effect of modulating IL-18 on the histopathological conditions of malaria infected mice. Methods: Plasmodium berghei ANKA infection in male ICR mice was used as a model for malaria infection. Modulation of IL-18 release was carried out by treat­ment of malarial mice with recombinant mouse IL-18 (rmIL-18) and recombinant mouse IL-18 Fc chimera (rmIL-18Fc) intravenously. Histopathological study and analysis were performed on major organs including brain, liver, spleen, lungs and kidney. Results: Treatment with rmIL-18Fc resulted in significant improvements on the histopathological conditions of the organs in malaria-infected mice. Conclusion: IL-18 is an important mediator of malaria pathogenesis and targeting IL-18 could prove beneficial in malaria-infected host.
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نویسندگان مقاله | Marzieh JABBARZARE
Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia


| Voon Kin CHIN
Dept. of Biomedical Sciences, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia


| Herni TALIB
Dept. of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia


| Mun Fei YAM
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia


| Siti Khadijah ADAM
Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia


| Haniza HASSAN
Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia


| Roslaini ABDUL MAJID
Dept. of Medical Microbiology and Parasitology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia,Selangor, Malaysia


| Che Norma MAT TAIB
Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia


| Mohamad Aris MOHD MOKLAS
Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia


| Mohamad TAUFIK HIDAYAT
Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia


| Hasidah MOHD SIDEK
School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Malaysia


| Rusliza BASIR
Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/304
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