این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Parasitology، جلد ۵، شماره ۳، صفحات ۱۱-۱۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Therapeutic Effect of Sodium Selenite and Zinc Sulphate as Sup-plementary with Meglumine Antimoniate( Glucantime®) Against Cutaneous Leishmaniasis In BALB/C Mice
چکیده انگلیسی مقاله Background: Successful therapy of leishmaniasis depends on effective cellular immune response. We evaluated the effectiveness of sodium selenite and zinc sulphate as known immunomodulator materials, in combination with Glucantime® in treatment of cutaneous leishmaniasis lesions resulting from Leishmania ma­jor in susceptible animal model. Methods: Thirty three female mice weighing 18-20 g at the age of 7-8 week infected with L. major were randomly divided into 3 groups: group1:  treated by sodium selenite (0.35 mg/kg for 30 days), group2: treated by zinc sulphate (2 mg/kg for 30 days) and group3: treated by distilled water (0.01 ml/gr body weight for 30 days) as control. All groups received Glucantime® as a standard anti- leishmanial agent (60 mg/kg, ip) for 14 days. To assess the results of treatment measurement of lesions size and parasitological tests were done weekly. Results: The lesion sizes increased continuously in sodium selenite group .Although, in zinc group did not in­crease compared to baseline But with considering the time- group interaction there was no significant difference between zinc and control group during this study.  There was no difference between lesion sizes and Leishmanial loads in the interventional and control groups, respectively. Conclusion: Sodium selenite and zinc sulphate at mentioned doses and duration of treatment did not show any treatment effect on cutaneous leishmaniasis caused by L. major in BALB/c mice. Increasing the dose of supplements and considering the follow up period after treatment can help more certain conclusion.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | F Zamani Sorkhroodi
Dept. of Nutrition and Biochemistry, School of Health, Tehran University of Medical Science, Iran


| AM Alavi Naeini
Dept. of Nutrition and Biochemistry, School of Health, Tehran University of Medical Science, Iran


| AR Zahraei Ramazani
Dept. of Entomology, School of Health, Tehran University of Medical Science, Iran


| MR Aghaye Ghazvini
Isfahan Center of Public Health Training and Research, Institute of Public Health Research, Tehran University of Medical Science, Iran


| M Mohebali
Dept. of Medical Parasitology and Mycology, School of Health, Tehran University of Medical Science, Iran


| SA Keshavarz
Dept. of Nutrition and Biochemistry, School of Health, Tehran University of Medical Science, Iran
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/141
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/69/article-69-1353898.pdf
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات