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Medical Journal of Islamic Republic of Iran، جلد ۱۱، شماره ۲، صفحات ۱۰۵-۱۰۹
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عنوان انگلیسی RELATIONSHIP BETWEEN SUCCINYLCHOLINEINDUCED APNEA AND DIBUCAINE NUMBER IN PATIENTS WITH GENETIC DEFICIENCY OF PLASMA CHOLINESTERASE
چکیده انگلیسی مقاله In this study, a commercially available kit in which propionylthiocholine is used as a substrate and a dibucaine solution to determine the variants of the enzyme were utilized. Plasma cholinesterase activity of 151 patients who underwent different operations was measured during a period of six months. The mean±SD of the enzyme activity in 150 patients was 4.39±1.17 kU/L .. Seventeen patients (11.2%) were found to have a serum cholinesterase activity of less th'an normal «3 Ku/L), but the period of apnea and the dibucaine number (DN) were found to be normal. Eight patients (5.3%) displayed an increased sensitivity to succinylcholine. Six of these patients (4%) were heterozygous for atypical enzyme with a mean period of apnea of 18.6 min (range 12-35 minutes) and had a dibucaine number of less than normal (‹80%). The DN of the other two patients (1.3%) who were homozygotes and had an exceedingly low atypical enzyme allele was 10% and 24%. The mean±SD DN value, in the 149 out of 151 patients was 84.41±2.91 %, and the DN ranged from 10-90% in these patients. The mean±SD apnea period in the 149 patients was 6.37±4.28 min.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله مهیندخت کیهانی | mahindukht keyhani
from the department of bio chemistry, iran university of medical sciences, and the department of anesthesiology, tehran university of medical sciences, tehran, islamic republic of iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

زاهد حسین خان | zahid hussain khan


نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-372&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Biological Sciences
نوع مقاله منتشر شده Original Research
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