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Molecular Biology Research Communications، جلد ۸، شماره ۱، صفحات ۲۷-۳۱
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عنوان انگلیسی Genetic polymorphism in ERCC5 and breast cancer risk
چکیده انگلیسی مقاله ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 females including one hundred breast cancer cases and age matched seventy-five healthy controls. Genotyping was performed with Tetra amplification-refractory mutation system (ARMS) PCR and products were observed through electrophoresis. Multivariate logistic regression was used to calculate odds ratio (OR) and 95% confidence interval (95% CI) investigating relationship between genotypes, clinical parameters and risk of breast cancer. Statistical analysis exhibited significant relationship between the TC genotype (OR=7.2, 95% CI=1.5-34.3) and increased breast cancer risk. Moreover, family history (OR=6.25; 95% CI= 2.61-15.00) and late menopause (OR=2.41; 95% CI=1.20-4.83) were found to be breast cancer associated risk factors. In conclusion, ERCC5 (rs1047768 T>C) polymorphism may contribute towards increased risk of breast cancer in Pakistani population.
کلیدواژه‌های انگلیسی مقاله ERCC5, breast cancer, NER, ARMS-PCR
نویسندگان مقاله Saima Malik |
Microbiology and Biotechnology Research Lab, Fatima Jinnah Women University, The Mall Rawalpindi

Sumaira Mubarik |
Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan, China

Mehreen Baig |
Surgical Unit, Fauji Foundation Hospital, Rawalpindi

Nosheen Masood |
Microbiology and Biotechnology Research Lab, Fatima Jinnah Women University, The Mall Rawalpindi

Nayyer Chaudhry |
Armed Forces Institute of Pathology, Rawalpindi

نشانی اینترنتی http://mbrc.shirazu.ac.ir/article_5100_a5acac91db6e4b62b874795805d08053.pdf
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