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Medical Journal of Islamic Republic of Iran، جلد ۱۱، شماره ۲، صفحات ۹۱-۹۷
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چکیده فارسی مقاله
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عنوان انگلیسی DIFFERENTIAL PRODUCTION OF IgM A ND IgA RHEU MATOID FACTORS IN PERIPHERAL BLOOD AND SYNOVIUM OF PATIENTS WITH RHEUMATOID A RTHRITIS
چکیده انگلیسی مقاله Total IgM, IgA, and IgM-rheumatoid factor (RF) and IgA-RF were quantitated in the serum and synovial fluid of 35 seropositive and 8 seronegative rheumatoid arthritis (RA) patients, using a sensitive enzyme-linked immunosorbent assay (ELISA). Mononuclear cells isolated from peripheral blood and synovial fluid of three seropositive patients were also stimulated in vitro with phorbol myristate acetate (PMA) and culture supernatants collected for measurement of total immunoglobulin (lg) and RF. Our results demonstrated that as a proportion of total Ig, IgM-RF and IgA-RF were significantly higher in the synovial fluid of seropositive patients compared to their serum level. Similar results were observed for in vitro stimulated culture supernatants from the same patients. This difference, however, was not evident in the seronegative group of patients. These results indicate that synovium could be considered as the original site of RF production in seropositive RA patients, and that different repertoires of Blymphocytes may be involved in RF production in peripheral blood and synovial tissues of affected joints.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله قاسم مسیبی | ghasem mosayyebi
from the dept. of immunology, school of public health, tehran university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

جعفر فرقانی زاده | jafar forghanizadeh
the dept. of rheumatology, hazrate rasool hospital, iran university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

بنفشه gholestan | banafsheh gholestan
the dept. of statistics and epidemiology, school of public health, tehran university of medical sciences, tehran, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فاضل شکری | fazel shokri
from the dept. of immunology, school of public health, tehran university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-369&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Immunology
نوع مقاله منتشر شده Original Research
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