این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Journal of Islamic Republic of Iran، جلد ۱۱، شماره ۱، صفحات ۴۳-۴۷
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چکیده فارسی مقاله
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عنوان انگلیسی THE DETECTION OF Mycobacterium tuberculosis BY PCR IN SPUTUM SAMPLES FROM LONG-TERMTREATED LEPROSY PATIENTS: ASSOCIATIONS WITH SKIN TEST RESULTS AND IMMUNOTHERAPY WITH Mycobacterium vaccae
چکیده انگلیسی مقاله As part of a series of investigations at Baba Baghi Leprosarium in lran, 44 long-treated leprosy patients were selected for our study. Samples of early morning sputum were obtained from each patient, examined by microscopy for acid-fast bacilli (AFB), and cultured for tubercle bacilli. These tests were negative, but the polymerase chain reaction (PCR) for an insertion sequence believed to be specific for Mycobacterium tuberculosis was applied to each sputum sample and those from six patients were found to be positive. Five of the six positive samples were from the 21 patients producing Koch-type responses to tuberculin, and none were from the 11 patients previously found to have skin-tissue fluid or sputum positive by PCR for Mycobacterium leprae. Whereas immunotherapy with killed Mycobacterium vaccae given nearly 2 years earlier to 23 of the patients strongly influenced PCR results for M. leprae (p= 0.0 I), it had no influence on results fm' tubercle bacilli. However, at a second sampling date 18 months later, the only 2 patients still positive by PCR for tubercle bacilli came from the placebo recipient group. The possible significance of the findings is discussed.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله a رفیع | a rafi
from the department of medical microbiology, school of medicine, tabriz university of medical sciences, tabriz

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

a ahmadlan | a ahmadlan
from the department of medical microbiology, school of medicine, tabriz university of medical sciences, tabriz

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

mh مبین | mh mobayen
the •baba baghi leprosy hospital tabriz


f فیوال | f feval
the •baba baghi leprosy hospital tabriz


y دولتی | y dowlati
the tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

k قاضی سعیدی | k ghazi saidi
the tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

aa ولایتی | aa velayati
the tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

jl stanford | jl stanford
the, department of bacteriology, university coliege london medical school, 67-73 riding house street, london wip7ld, uk
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-400&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Microbiology and Anatomy
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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