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Medical Journal of Islamic Republic of Iran، جلد ۱۱، شماره ۱، صفحات ۱۵-۱۷
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عنوان انگلیسی ANTINEUTROPHIL CY TOPLASMIC AUTOANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS
چکیده انگلیسی مقاله Antineutrophil cytoplasmic autoantibodies (ANCA) were first described in patients with necrotizing glomerulonephritis. The original observation passed unnoticed until an association was made between ANCA and active Wegener's granulomatosis. Since then, tremendous progress has been made in elucidating the association between ANCA subtypes and clinicopathologic syndromes, and the potential pathologic role of ANCA in vascular inflammation. The gold standard method for ANCA detection is indirect immunofluorescence (IIF) microscopy of ethanol-fixed cells. By this technique two general patterns of ANCA, acytoplasmic pattern (c-ANCA) and a perinuclear pattern (P-ANCA) can be identifed. Recently some reports have been published concerning the prevalence, subtypes, role and specificity of ANCA.ln this study we searched for ANCA prevalence, subtypes, and its relationship with disease activity in SLE patients by IIF technique. Our results showed that all normal subjects were ANCA negative, while at least 50% of patients were ANCA positive (majority c-ANCA type). Statistical analysis revealed that there is no correlation between the presence of ANCA and disease activity (p< 0.01).
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نویسندگان مقاله m وجگانی | m vodjgani
from the dept. of lmmunology, faculty of medicine, tehran university of medical sciences, tehran, islamic republic of iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

f نصیری زاده | f nassiri zadeh


j حاجتی | j hadjati


m akbarlan | m akbarlan


نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-394&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Immunology
نوع مقاله منتشر شده Original Research
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