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Medical Journal of Islamic Republic of Iran، جلد ۱۰، شماره ۴، صفحات ۲۹۱-۲۹۷
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عنوان انگلیسی PURIFICATION AND CHARACTERIZATION OF PROTEIN ANTIGENS ISOLATED FROM MYCOBACTERIUM TUBERCULOSIS (H37Rv STRA IN) AND THEIR EFFECTS ON CELL-MEDIATED IMMUNE RESPONSES IN GUINEA PIGS
چکیده انگلیسی مقاله Mycobacterium tuberculosis (H37Rv strain) was used in this study. The bacterial cells were disintegrated by sonication. The separation and characterization of the soluble molecules were attempted by various techniques including gel filtration, ion exchange chromatographies and polyacrylamide gel electrophoresis, using SDS and 2ME. Eight protein molecules with molecular weights ranging from 6.3 up to 204 kD were identified. Following reduction of the 204 kD molecule with 2ME, six smaller molecules with 12a, 12b, 21, 29,45 and 81.5 kD molecular weights were obtained. All isolated protein molecules were able to induce delayed hypersensitivity skin reaction in sensitized guinea pigs and proliferation of T-cells in vitro. Regarding the fact that an effective protective immunity in tuberculosis is dependent mainly on T-cell response, it is suggested that the molecules isolated in this study may be useful in conceiving a vaccine and/or diagnostic tests for tuberculosis.
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نویسندگان مقاله a زواران حسینی | a zavaran hosseini
from the department of immunology, tarbiat modarres university

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

mb اسلامی | mb eslami
the dept. of immunology school of public health, tehran university of medical sciences, tehran, islamic republic of iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m جلالی | m jalali
the dept. of biochemistry, school of public health, tehran university of medical sciences, tehran, islamic republic of iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-415&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Immunology
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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