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Medical Journal of Islamic Republic of Iran، جلد ۱۰، شماره ۳، صفحات ۱۸۳-۱۸۹
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عنوان انگلیسی SHORT TERM VARIATION OF ATROPINE BLOCKADE IN THE TRACHEOBRONCHIAL TREE OF ASTHMATIC SUBJECTS
چکیده انگلیسی مقاله In asthmatic subjects there is a pronounced diurnal variation in bronchial responsiveness. If this phenomenon is due to variation in factors that control drug delivery, then it should be paralleled by a similar variation in competitive antagonist blockade. In order to study this possibility, we performed the methacholine challenge test and after 45 minutes, administered atropine by inhalation. Methacholine rechallenge was performed 25 minutes after premedication with atropine. Bronchial responsiveness to methacholine(pB3s) and atropine blockade was then measured. Eight normal subjects and 9 asthmatic patients were tested on two separate occasions, one in the morning at 08:00 hours and the other in the evening at 18:00 hours with at least 48 hours gap between them. In normal subjects there was no significant difference between morning and evening concerning airway caliber, bronchial responsiveness to methacholine and atropine blockade. In asthmatic patients there was a significant difference between morning and evening in bronchial responsiveness to methacholine (P< 0.001) and atropine blockade (P< 0.001), although there was no significant difference in airway caliber. The possible explanation for' enhanced atropine blockade as well as methacholine responsiveness in asthmatic subjects in the morning is increased bronchial and tissue permeability due to worsening bronchial inflammation in the early morning leading to increased drug delivery to active sites in the airways.
کلیدواژه‌های انگلیسی مقاله Short term variation, atropine blockade, asthma.
نویسندگان مقاله mh بسکابادی | mh boskabady
from the department of physiology. ghaem medical center. mashhad university of medical sciences. mashhad. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

pd snashall | pd snashall
the dept of medicine. charing cross and westminster medical school. fulham palace road. london w6 brf. uk
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-424&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Physiology
نوع مقاله منتشر شده Original Research
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