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Medical Journal of Islamic Republic of Iran، جلد ۸، شماره ۴، صفحات ۲۱۱-۲۱۵
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عنوان انگلیسی TRIAL OF A NON-LIVING CRUDE VACCINE AGAINST ZOONOTIC CUTANEOUS LEISHMANIASIS
چکیده انگلیسی مقاله A field trial was canied outon60 volunteers selected in Yazd province, central Iran, with a vaccine containing killed promastigotes of L. major prepared by the Razi Institute, Hessarak. During these phase I studies which lasted for more than two years, we examined acceptable doses of the vaccine alone or mixed with BCG. The results so far indicate that 50 to 1000 µg of the vaccine alone can be well tolerated without major side-effects. The mixture of BCG with 400 µg of the vaccine produced pain and itching in five out of six volunteers, a self-limiting lymphadenopathy in one out of six, and fever in three out of six. Further trials are planned with reduced doses of BCG. The leishmania skin test became positive in a high proportion of the treated individuals after vaccination. Circulating antibodies were detected from two weeks to one month after vaccination.
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نویسندگان مقاله m محبعلی | m mohebali
from the school of public health and institute of public health research, tehran university of medical science

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

eh javadlan | eh javadlan
from the school of public health and institute of public health research, tehran university of medical science

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

r fesharakl | r fesharakl
department of protozoology and entomology, razi state serum vaccine institute, tehran,


m محمدزاده | m mohammadzadeh
amir al –momenin hospital, shahid sadooghi university of medical sciences, yazd. islamic republic of iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (Shahid sadooghi university of medical sciences)

a nadlm | a nadlm
from the school of public health and institute of public health research, tehran university of medical science

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

gh tahyildar bidruni | gh tahyildar bidruni
from the school of public health and institute of public health research, tehran university of medical science

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

a مصداقی نیا | a mesdaghinia
from the school of public health and institute of public health research, tehran university of medical science

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-560&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Health
نوع مقاله منتشر شده Original Research
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