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Medical Journal of Islamic Republic of Iran، جلد ۸، شماره ۳، صفحات ۱۴۹-۱۵۳
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چکیده فارسی مقاله
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عنوان انگلیسی AUTOANTIBODIES AGAINST THYR OID CONSTITUENTS AND CIC IN GRAVES' DISEASE ASSOCIATED WITH EXOPH THALMUS
چکیده انگلیسی مقاله 32 patients (19 female. 13 male)• suffering from Graves' disease with exophthalmus and five without exophthalmus were studied for various autoantibodies including anti-thyroglobulin (ATAB). anti-microsomal antibody (AMAB). anti-parietal antibodies (APAB) and also circulating immune complex (CrC). 43 normal subjects were tested concurrently. Immunofluorescent technique was employed for autoantibody detection. Frozen sections of human thyroid tissue and rat stomach were utilized as antigen sources for thyroid and parietal CIC estimated by PEG (polyethylene glycol) precipitation method and the specific classes of immunoglobulins were detected by SRlD (single radial immunodiffusion). The results were analyzed statistically. From the point of view of presence of antibodies. there were significant differences between patients and control groups (P= 0.(05). Comparing Graves' with or without exophthalmus. no significant difference was seen between autoantibody levels. but higher titers of CIC were elucidated in the latter group. We will discuss that autoantibodies have an important role in thyroid autoimmune diseases and also that CIC may have a critical role in the pathogenesis of exophthalmus associated with Graves' disease
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نویسندگان مقاله s رفیعی | s rafiei
from the dept. of immunology school of medicine, tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m nakhjevani | m nakhjevani
from the dept. of endocrinology, school of medicine, tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m قراگوزلو | m gharagouzlou
bu ali sina university of medicalsciences, hamedan university, hamedan, i.r.iran.

سازمان اصلی تایید شده: دانشگاه بوعلی سینا (Bu ali sina university)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-575&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Immunology
نوع مقاله منتشر شده Original Research
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