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Medical Journal of Islamic Republic of Iran، جلد ۷، شماره ۴، صفحات ۲۶۳-۲۶۸
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عنوان انگلیسی SIGNIFICANT CHANGES IN THE ACTIVITY OF GABATRANSAMINASE AND SUCCINATE SEMIALDEHYDE DEHYDROGENASE OF MOUSE HYPOTHALAMUS FOLLOWING PERIPHERAL INJECTION OF CHOLECYSTOKININ-8 AND/OR CAERULEIN
چکیده انگلیسی مقاله The activities of 4-aminobutyric-2-oxoglutaric acid transaminase (GABA-T) and succinate semialdehyde dehydrogenase (SSADH) were determined in mouse hypothalamus after peripheral injections of cholecystokinin-8 (CCK-X)and/or caerulein (CLN). GABA transaminase activity was measured utilizing endogenous succinate semialdellyde dehydrogenase to convert the product of GAB A-T, succinate semialdehyde, to succinate. The concurrently formed NADH was used as an estimate of GABA-T activity. Similarly, the activity of SSADH was determined in terms of NADH. Injection of CCK-8 and/or CLN inhibited the GABA-T and SSADH activities in dose-dependent responses. The activities of GAB A-Tand SSADH were diminished by 52 and 66 percent respectively, 30 minutes after injection of CCK-8 (50 µg/kg body weight).Similarly, peripheral injection of CLN (50 µg/kg body weight) reduced the activity of GABA-T and SSADH by 56 and 65 percent respectively, in 30 minutes. Using ill vitro models, the full activities of GABA-T and/ or SSADH, after incubation with CCK-8 and/or CLN, were restored following 30 hours of dialysis at 4°C. These results indicate direct and reversible interactions between the catabolizing enzymes of GABA (GABA-T and SSADH) and the peptides CCK-8 and CLN.
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نویسندگان مقاله r یزدان پرست | r yazdanparast
from the institute of biochemistry and biophysics, university of tehran

سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

d قوجق | d qujeq
the dept. biochemistry, tarbiat modarres university, tehran, islamic republic of iran.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-622&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Biological Sciences
نوع مقاله منتشر شده Original Research
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