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Medical Journal of Islamic Republic of Iran، جلد ۷، شماره ۳، صفحات ۱۸۷-۱۹۱
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عنوان انگلیسی PHARMACOLOGICAL STUDIES ON NOVEL BASIC AMINOALKYL ARYL ETHERS AS POTENTIAL LOCAL ANAESTHETICS
چکیده انگلیسی مقاله Following our previous investigations on certain new aminoalkyl aryl ethers, which showed promising and outstanding local anaesthetic properties, the local anaesthetic activity and duration of action of a further selection of four novel derivatives of the above-mentioned series, used as hydrochloride salts, have been determined by the ill vivo rat sciatic nerve test. These are: N,N-dimethyl-2-(2,6-ditert- butylphenoxy)ethylamine N, N-dimethyl-2-(4-butoxyphenoxy) ethylamine N, N-dimethyl-2-(2,6-di-sec-butylphenoxy)ethylamine and N,N-diethyl-2-(4-secbutylphenoxy) ethylamine. The tests have been performed by a double blind, controlled trial (at the later stage) and in two stages. Bupivacaine hydrochloride has been employed as the standard and normal saline as the control. The complete loss of motor function of the injected limb of the animal is considered as a positive response, which is assessed by observing the animal gait and ability to climb up a sloping wire mesh. The test compounds have exhibited shorter duration of motor paralysis than that of the standard and comparable rates of both onset of action, and recovery time from full analgesia. They also have shown neither apparent systemic nor local side effects such as edema, swelling, induration, ulceration, necrosis, or irritation.
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نویسندگان مقاله d al سعدی | d al saadi
from the school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

we sneader | we sneader
school of pharmacy and pharmacology, university of strathclyde, glasgow, scotland.
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-633&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmacology
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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