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Medical Journal of Islamic Republic of Iran، جلد ۷، شماره ۲، صفحات ۱۰۱-۱۰۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی A SPECIFIC, SENSITIVE, AND ONE-STEP EXTRACTION RADIOIMMUNOASSAY OF TESTOSTERONE FOR CLINICAL DIAGNOSIS
چکیده انگلیسی مقاله Testosterone was measured using antibodies raised against testosterone II B-carboxymethyl ether bovine serum albmin (T-IIB-CME-BSA) and testosterone 3- O-carboxymethyl oxime-BSA as immunogen. The antibody produced in this study exhibits minimal cross reactivity with the structurally related steroids specially 5 dihydrotestosterone (5 DHD. This allows to ommit the clean up step and measure testosterone in female serum samples accurately with a high sensitivity, precision, and specificity. The coefficent of variation (CY), standard deviation (SD) and standard error of mean (SE) were all in acceptable ranges. Antibody-bound and free steroids were separated by addition of dextran coated charcoal. The method was applied to a set of clinical samples, the results of which are discussed in this communication. The assay was compared with the available imported kits using 125 I as tracer. The correlation coefficient obtained is calcualted to be r= 0.96, showing that the results obtained by these two methods are fully comparable and the assay may be replaced with the similar preparations imported from abroad.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله gh r اسدی کرم | gh r asadikaram
from the department of biochemistry, school of medical sciences, tarbiat modarres university, tehran, i.r.lran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

mj رسایی | mj rasaee
from the department of biochemistry, school of medical sciences, tarbiat modarres university, tehran, i.r.lran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

s آل آقا | s ale agha
the quality.control department, razi research institute, karaj, i.r. iran


gl kumari | gl kumari
the department of reproductive biomedicine, national institute of health and family welfare,new delhi, india


pn رایو | pn rao
the department of organic chemistry. south west foundation of biomedical research, san antonio, texas, usa.
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-644&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Clinical Biochemistry
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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