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Medical Journal of Islamic Republic of Iran، جلد ۷، شماره ۱، صفحات ۲۹-۳۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی VARIATIONS BY EPINEPHRINE OF HEPATIC AND SERUM AMINOTRANSFERASES AND LACTATE DEHYDROGENASE IN THE RAT
چکیده انگلیسی مقاله Incubation of rat hepatocytes with epinephrine inhibited alanine aminotransferase (ALT) (80%) and aspartate aminotransferase (AST) (53%) activities with no effect on lactate dehydrogenase (LDH) activity. Injection of epinephrine caused a progressive increase with time in hepatic LDH activity, being 52% at 24 h. Preinjection with propranolol eliminated the hormone effect and caused further inhibition (28%) of the enzyme activity. Liver ALT activity in ephinephrine-treated animals decreased by 37% at 24 h, "_.er which it rose again to the control levels at 48 h. Propranolol raised epinephrine-induced enzyme inhibition up to 53%. Phentolamine, however, abolished the inhibitory effect. The activity of hepatic AST was not affected by epinephrine. Plasma ALT and LDH activity increased in epinephrine injected rats by 55% and 75%, respectively, but AST activity did not change. Propranolol alone stimulated serum ALT (41 %) and AST (21 %) activities. The data suggest that epinephrine exerts its effects on these enzymes through a-receptor activation and/or via the cell lesion resulting in the change of intra- and extracellular enzyme levels.
کلیدواژه‌های انگلیسی مقاله Epinephrine. aminotransferase. lactate dehydrogenase
نویسندگان مقاله b حقیقی | b haghighi
from the department of biochemistry, isfahan university of medical sciences, isfahan, lran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

m سوزنگر | m suzangar


z mostajaboldaveh | z mostajaboldaveh


نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-658&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Biological Sciences
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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