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Iranian Journal of Medical Sciences، جلد ۳۲، شماره ۱، صفحات ۴۵-۴۷
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عنوان انگلیسی Effects of Orange, Tangerine, and Grapefruit Juices on Pharmacokinetic Parameters of Cyclosporine A in Rats
چکیده انگلیسی مقاله This study was designed to investigate the effects of tangerine, orange, and grapefruit juice on the pharmacokinetic pattern of cyclosporine A in rats. Forty male Sprague-Dawley rats were divided into four groups to receive water, orange, tangerine, or grapefruit juices respectively. Water or juices (10 ml/kg) were given orally twice a day for 3 days. Three hours after the 5th dose, cyclosporine A was given as a single oral dose (5 mg/kg). Blood samples (2 ml) were collected at 30, 120, and 240 min after administering cyclosporine A, and area under time-concentration curve (AUC), Maximal serum concentration (Cmax),and time to reach maximal concentration (Tmax) were calculated using one-compartment method. Orange juice, but not tangerine or grapefruit juices, significantly increased the AUC and Cmax of cyclosporine A compared with water. The three juices significantly decreased the Tmax of cyclosporine A. The findings suggest that Thompson Novel's orange juice increased the bioavailability of oral administration of cyclosporine A formulation in rats.
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نویسندگان مقاله Hadi Sorkhi |


A.A. Moghadamnia |


M. PourAmir |


A.R. Firoozjahi |


F. Oaliaee |


H. Karbalaee Aghamolki |


نشانی اینترنتی http://ijms.sums.ac.ir/article_43354_df41acb080565e1f5e10bcf4fb8364ac.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-1611553.pdf
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