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Medical Journal of Islamic Republic of Iran، جلد ۵، شماره ۱، صفحات ۹-۱۴
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عنوان انگلیسی CORRELATION BETWEEN EXPRESSION OF CLASS I ANTIGEN AND DEVELOPMENT OF TUMOUR INFILTRATING LYMPHOCYTES (TILS) FROM TUMOUR BIOPSIES OF PATIENTS WITH BLADDER CANCER
چکیده انگلیسی مقاله This report presents the findings of TIL development from tumour biopsies of patients with bladder cancer. Analysis of tissue sections showed the presence of T cells in intra-epithelial layer in 8 of 12 cases investigated. In a larger group of patients, TILs were established from 7 of 20 cases and expansion of these cells in Interleukin-2 (IL-2) in the presence of conditioned medium (CM) resulted in increase cell number to as many as 100 fold. Cell surface antigen profile of the cells showed characteristics of activated T cells and showed cytotoxic activity against tumour cell lines K256 and Daudi. In one case where TILs and tumour cell line from the same individual was established, it was found that TILs showed low levels of cytotoxicity against the autologous tumour cells. Investigation of correlation between class I antigen expression and TIL development revealed that all the 7 cases of positive TILs were established from tissue expressing normal levels of free chain of class I antigens. These results are indicative of the presence of IL-2-expandable T cells in tumour biopsy of patients with bladder cancer and demonstrate that the successful expansion of these cells correlates with the normal expression of class I antigens.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله آمی نوری | ame nouri
depts.of• medical oncology


avl دوست سانتوز | avl dos santos
immunology of the royal london hospital, uk


a شمسا | a shamsa
mashhad university of medical sciences, mashhad, islamic republic of iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-715&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Oncology
نوع مقاله منتشر شده Original Research
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